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Clinical Efficacy of Patients With Secondary Bacteremia Treated With Omadacycline: Results From Phase 3 Acute Bacterial Skin and Skin Structure Infections and Community-Acquired Bacterial Pneumonia Studies

Open Forum Infect Dis. 2021 Jun 18;8(6):ofab136. doi: 10.1093/ofid/ofab136.

Genomic evidence of SARS-CoV-2 reinfection case with the emerging B.1.2 variant in Brazil

J Infect. 2021 May 21:S0163-4453(21)00256-5. doi: 10.1016/j.jinf.2021.05.014. Online ahead of print.NO ABSTRACTPMID:34029627 | DOI:10.1016/j.jinf.2021.05.014

Genomic surveillance activities unveil the introduction of the SARS-CoV-2 B.1.525 variant of interest in Brazil: Case Report

J Med Virol. 2021 May 15. doi: 10.1002/jmv.27086. Online ahead of print.ABSTRACTThe appearance of new variants of SARS-CoV-2 has recently challenged public health authorities with respect to tracking transmission and mitigating the impact in the evolving pandemic across countries. B.1.525 is considered a variant under investigation (VUI) since it carries specific genetic signatures present in P.1, B.1.1.7 and B.1.351. Here we report genomic evidence of the first likely imported case of the SARS-CoV-2 B.1.525 variant, isolated in a traveler returning from Nigeria.

Risk of cardiovascular mortality, stroke and coronary heart mortality associated with aircraft noise around Congonhas airport, São Paulo, Brazil: a small-area study

Environ Health. 2021 May 13;20(1):59. doi: 10.1186/s12940-021-00746-7.ABSTRACTBACKGROUND: Noise pollution is increasingly recognised as a public health hazard, yet limited evidence is available from low- and middle-income countries (LMIC), particularly for specific sources.

Identifying key questions in the ecology and evolution of cancer

Evol Appl. 2021 Feb 8;14(4):877-892. doi: 10.1111/eva.13190. eCollection 2021 Apr.ABSTRACTThe application of evolutionary and ecological principles to cancer prevention and treatment, as well as recognizing cancer as a selection force in nature, has gained impetus over the last 50 years. Following the initial theoretical approaches that combined knowledge from interdisciplinary fields, it became clear that using the eco-evolutionary framework is of key importance to understand cancer.

SARS-CoV-2 shifting transmission dynamics and hidden reservoirs potentially limit efficacy of public health interventions in Italy

Commun Biol. 2021 Apr 21;4(1):489. doi: 10.1038/s42003-021-02025-0.ABSTRACTWe investigated SARS-CoV-2 transmission dynamics in Italy, one of the countries hit hardest by the pandemic, using phylodynamic analysis of viral genetic and epidemiological data. We observed the co-circulation of multiple SARS-CoV-2 lineages over time, which were linked to multiple importations and characterized by large transmission clusters concomitant with a high number of infections. Subsequent implementation of a three-phase nationwide lockdown strategy greatly reduced infection numbers and hospitalizations.

Field and classroom initiatives for portable sequence-based monitoring of dengue virus in Brazil

Nat Commun. 2021 Apr 16;12(1):2296. doi: 10.1038/s41467-021-22607-0.ABSTRACTBrazil experienced a large dengue virus (DENV) epidemic in 2019, highlighting a continuous struggle with effective control and public health preparedness. Using Oxford Nanopore sequencing, we led field and classroom initiatives for the monitoring of DENV in Brazil, generating 227 novel genome sequences of DENV1-2 from 85 municipalities (2015-2019). This equated to an over 50% increase in the number of DENV genomes from Brazil available in public databases.

Short report: Introduction of chikungunya virus ECSA genotype into the Brazilian Midwest and its dispersion through the Americas

PLoS Negl Trop Dis. 2021 Apr 16;15(4):e0009290. doi: 10.1371/journal.pntd.0009290. eCollection 2021 Apr.ABSTRACTSince introduction into Brazil in 2014, chikungunya virus (CHIKV) has presented sustained transmission, although much is unknown about its circulation in the midwestern states. Here, we analyze 24 novel partial and near complete CHIKV genomes from Cuiaba, an urban metropolis located in the Brazilian midwestern state of Mato Grosso (MT). Nanopore technology was used for sequencing CHIKV complete genomes.

Co-morbidities and mortality in patients with sickle cell disease in England: A 10-year cohort analysis using hospital episodes statistics (HES) data

Blood Cells Mol Dis. 2021 Apr 1;89:102567. doi: 10.1016/j.bcmd.2021.102567. Online ahead of print.ABSTRACTPatients with a primary diagnosis of sickle cell disease (SCD) with or without crisis during the 10-year period January 2009 to December 2018 were identified in the HES Admitted Patient Care (APC) dataset and matched with the Office for National Statistics (ONS) mortality dataset. Three sub-cohorts were defined: 'crises', 'transfusions' and 'other SCD'.

Evolutionarily stable strategies are well studied in periodically fluctuating populations

Proc Natl Acad Sci U S A. 2021 May 4;118(18):e2102001118. doi: 10.1073/pnas.2102001118.NO ABSTRACTPMID:33853857 | DOI:10.1073/pnas.2102001118