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Dr. Uri Obolski

Research Interests

My main research interests are modelling and statistical analysis of processes underlying infectious diseases, with a particular interest in drug resistance. Currently I research the interactions between vaccination and changes in antibiotic resistance frequencies in Streptococcus pneunoniae.

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1.Barzel, A., Obolski, U., Gogarten, P., Kupiec, M. and Hadany, L. 2011. Home and Away: The evolutionary dynamics of homing endonucleases. BMC Evolutionary Biology 11:324.

2.Obolski, U., & Hadany, L. 2012. Implications of stress-induced genetic variation for minimizing multidrug resistance in bacteria. BMC Medicine 20:89.

3.Khait, R., Obolski, U., Hadany, L., Genin, A. 2013. Food Selectivity and Diet Switch Can Explain the Slow Feeding of Herbivorous Coral-Reef Fishes during the Morning. PLoS ONE 8(12).

4.Obolski, U†., Alon, D†., Hadany L., Stein, G. 2014. Resistance Profiles of CoNS Contaminating Blood Cultures Predict Pathogen Resistance and Patient Mortality. Journal of Antimicrobial Chemotherapy, dku156.

5.Hazak, O., Obolski, U., Prat, T., Friml, J., Hadany, L., and Yalovsky, S. 2014. Bimodal regulation of ICR1 levels generates self-organizing auxin distribution. PNAS, doi:10.1073/pnas.1413918111.

6.Katz, E., Nisani, S., Yadav, B. S., Woldemariam, M. G., Shai, B., Obolski, U.,   Ehrlich, M., Eilon Shani, E., Jander, G., Chamovitz, D. A. 2015. The glucosinolate breakdown product indole‐3‐carbinol acts as an auxin antagonist in roots of Arabidopsis thaliana. The Plant Journal, doi: 10.1111/tpj.12824.

7.Obolski, U., Stein, G., Hadany, L. 2015. Antibiotic restriction might facilitate the emergence of Multi-Drug Resistance. PLoS Computational Biology, 11(6): e1004340. doi: 10.1371/journal.pcbi.1004340.

8.Obolski, U., Hadany, L., Abelson, A. 2016. Potential contribution of fish restocking to the recovery of deteriorated coral reefs: an alternative restoration method? PeerJ 4:e1732

9.Obolski, U., Dellus-Gur, E., Stein, G. Y., & Hadany, L. 2016. Antibiotic cross-resistance in the lab and resistance co-occurrence in the clinic: Discrepancies and implications in E. coli. Infection, Genetics and Evolution, 40, 155-161.

10.Abelson, A., Obolski, U., Regoniel, P. & Hadany, L. 2016. Restocking Herbivorous Fish Populations as a Social-Ecological Restoration Tool in Coral Reefs. Frontiers in Marine Science, 3, doi:10.3389/fmars.2016.00138.

11.Zaritsky, A., Obolski, U., Gan, Z., Reis, C. R., Kadlecova, Z., Du, Y., Schmid, SL., Danuser, G. 2017. Decoupling global biases and local interactions between cell biological variables. eLife, 6, e22323.

12.Obolski, U†., Lewin-Epstein†, O., Even-Tov, E., Ram, Y., & Hadany, L. 2017. With a little help from my friends: cooperation can accelerate the rate of adaptive valley crossing. BMC Evolutionary Biology, 17(1), 143.

13.Lourenço, J., Watkins, E.R., Obolski, U., Peacock, S.J., Morris, C., Maiden M.C.J., Gupta, S. Lineage structure of Streptococcus pneumoniae is driven by immune selection on the groEL heat-shock protein.  Scientific reports 7.1 (2017): 9023.

14.Lebel, M., Obolski, U., Hadany, L., Sapir Y. 2017. Pollinator-mediated selection on floral size and tube color in Linum pubescens: can differential behavior and preference in different times of the day maintain dimorphism? Ecology and Evolution. DOI: 10.1002/ece3.3683.

15.Obolski, U†., Ram, Y†., Hadany, L. Key issues review: evolution on rugged adaptive landscapes. 2018. Reports on Progress in Physics. 81(1): p. 012602.

16.Obolski, U., Lourenço, J., Thompson, C., Thompson, R., Gori, A., Gupta, S. Vaccination can drive an increase in frequencies of antibiotic resistance among non-vaccine serotypes of Streptococcus pneumoniae. Accepted for publication in PNAS. BioRxiv: