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Dr. Katrina Lythgoe

Research Interests

I apply ecological and evolutionary theory to better predict the evolutionary dynamics of infectious disease in humans and other species, with the ultimate aim of informing public health decisions.  In particular, I am interested in disentangling the, often conflicting, selection pressures acting on pathogens at different ecological levels, and to assess the impact this has on the evolutionary epidemiology of infectious disease.  My approach is inter-disciplinary in nature, including the application and development of evolutionary theory, using and making sense of next generation sequence data, and applying epidemiological theory. The current focus of my research is on HIV and Hepatitis C, but the theory I develop has implications for our understanding of infectious disease more widely. 

Contact Details

Dr Katrina Lythgoe - University of Oxford, Department of Zoology, OX1 3PS

+44 (0)1865 281 896

http://www.zoo.ox.ac.uk/people/view/lythgoe_k.htm

Selected Publications

Lythgoe, K. A., A. Gardner, O. Pybus, J. Grove 2017. Short sighted virus evolution and a germline hypothesis of chronic viral infections. Trends in Microbiology 25(5): 336-348 (Invited article for Special Issue: From One to Many)

Doekes, H., C. Fraser & K.A. Lythgoe 2017. Effect of the latent reservoir on the evolution of HIV at the within- and between-host scales. PLoS Computational Biology 13(1): e1005228

Blanquart, F., M. K. Grabowski, J. Herbeck, F. Nalugoda, D. Serwadda, M. A. Eller, M. L. Robb, R. Gray, G. Kigozi, O. Laeyendecker, K. A. Lythgoe, G. Nakigozi, T. C. Quinn, S. J. Reynolds, M. J. Wawer, C. Fraser 2016. A transmission-virulence evolutionary trade-off explains attenuation of HIV-1 in Uganda. eLife 5: e20492

Lythgoe, K.A., F. Blanquart, L. Pellis & C. Fraser 2016. Large variations in viral load explained by shifting-mosaic metapopulation dynamics. PLoS Biol 14(10): e1002567

Fraser, C., K. Lythgoe*, G.E. Leventhal, G.Shirreff, T.D. Hollingsworth, S. Alizon, S. Bonhoeffer* 2014. Virulence and pathogenesis of HIV-1 infection: an evolutionary perspective. Science 343:1243727 (*indicates equal contribution).

van de Vijver, D.A.M.C., Nichols, B.E., Abbas, U., Cambiano, V., Eaton, J., Glaubius, R., Lythgoe, K.A., Mellors, J., Phillips, A., Sigaloff, K.C. & T.Hallett 2013. Pre-exposure prophylaxis (PrEP) will have a limited impact on the prevalence of HIV-1 drug resistance in sub-Saharan Africa: Comparison of mathematical models. AIDS DOI:10.1097/01.aids.0000433237.63560.20

Lythgoe, K.A.*, L.Pellis* & C. Fraser 2013. Is HIV short-sighted? Insights from a multi-strain nested model. Evolution DOI:10.1111/evo.12166 (*indicates joint first authorship).

Lythgoe, K.A. & C. Fraser 2012. New insights into the evolutionary rate of HIV-1 at the within- and between-host levels. Proceedings of the Royal Society B, 279, 3367-3375 

Lythgoe, K.A., L.J. Morrison, A.F. Read & J.D. Barry, 2007. Parasite-intrinsic factors can explain ordered progression of trypanosome antigenic variation. Proceedings of the National Academy of Science USA 104, 8095-8100 

Barry, J.D., L. Marcello, L.J. Morrison, A.F. Read, K. Lythgoe, N. Jones, M. Carrington, G. Blandin, U. Böhme, E. Caler, C. Hertz-Fowler, H. Renauld, N. El-Sayed & M. Berriman 2005. What the genome sequence is revealing about trypanosome antigenic variation. Biochemical Society Transactions 33, 986-989