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Dr James Iles

Research interests

My DPhil focused on the diversity and demographic history of the hepatitis C virus in central Africa. My postdoctoral research models the antigenic evolution of influenza and HIV, particularly focusing on the impact of highly related strains co-circulating in a population. Other general research interests include next-generation sequencing, phylodynamics, and the factors that determine the emergence of novel pathogens into human populations.

Contact details

Email: james.iles@zoo.ox.ac.uk

Publications

  • Iles JC, Raghwani J, Harrison GLA, Pepin J, Djoko CF, Tamoufe U, Lebreton M, Schneider BS, Fair JN, Tshala FM, Kayembe PK, Muyembe JJ, Edidi-Basepeo S, Wolfe ND, Simmonds P, Klenerman P, Pybus OG (2014) Phylogeography and molecular epidemiology of hepatitis C virus genotype 4 in Africa. Virology 464-465:233-43.

  • Markov PV, Gray RR, Iles JC, Pybus OG. The evolutionary epidemiology of the hepatitis C virus. In Parasite diversity and diversification: evolutionary ecology meets phylogenetics (S. Morand, B. Krasnov, T. Littlewood, eds.) Cambridge University Press. In press.

  • Iles JC, Harrison GLA, Lyons S, Djoko CF, Tamoufe U, Lebreton M, Schneider BS, Fair JN, Tshala FM, Kayembe PK, Muyembe JJ, Edidi-Basepeo S, Wolfe ND, Klenerman P, Simmonds P, Pybus OG (2013) Hepatitis C virus infections in the Democratic Republic of Congo exhibit a cohort effect. Infection, Genetics & Evolution 19:386-94.

  • Hall AR, Iles JC, MacLean RC (2011) The fitness cost of rifampicin resistance in Pseudomonas aeruginosa depends on demand for RNA polymerase. Genetics 187:817-22.