My DPhil focused on the diversity and demographic history of the hepatitis C virus in central Africa. My postdoctoral research models the antigenic evolution of influenza and HIV, particularly focusing on the impact of highly related strains co-circulating in a population. Other general research interests include next-generation sequencing, phylodynamics, and the factors that determine the emergence of novel pathogens into human populations.
Iles JC, Raghwani J, Harrison GLA, Pepin J, Djoko CF, Tamoufe U, Lebreton M, Schneider BS, Fair JN, Tshala FM, Kayembe PK, Muyembe JJ, Edidi-Basepeo S, Wolfe ND, Simmonds P, Klenerman P, Pybus OG (2014) Phylogeography and molecular epidemiology of hepatitis C virus genotype 4 in Africa. Virology 464-465:233-43.
Markov PV, Gray RR, Iles JC, Pybus OG. The evolutionary epidemiology of the hepatitis C virus. In Parasite diversity and diversification: evolutionary ecology meets phylogenetics (S. Morand, B. Krasnov, T. Littlewood, eds.) Cambridge University Press. In press.
Iles JC, Harrison GLA, Lyons S, Djoko CF, Tamoufe U, Lebreton M, Schneider BS, Fair JN, Tshala FM, Kayembe PK, Muyembe JJ, Edidi-Basepeo S, Wolfe ND, Klenerman P, Simmonds P, Pybus OG (2013) Hepatitis C virus infections in the Democratic Republic of Congo exhibit a cohort effect. Infection, Genetics & Evolution 19:386-94.
Hall AR, Iles JC, MacLean RC (2011) The fitness cost of rifampicin resistance in Pseudomonas aeruginosa depends on demand for RNA polymerase. Genetics 187:817-22.