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Coevolution

Coevolution between hosts and their parasites has been proposed as a fundamental driver of diversity and is believed to be necessary for the evolution and maintenance of a wide array of biological phenomena including sex and local adaptation.Our current projects in this area include:

  • The coevolution of bacteria with bacteriophages, and the effects of spatial structuring
  • How pathogen selection has affected the genomic organisation of the Major Histocompatibility Complex (MHC) and Killer-cell Immunoglobulin-like Receptor (KIR) gene families in humans.
  • The evolutionary significance of immune deficiency

References

  1. Gupta S & Hill AVS (1995) Dynamic interactions in malaria: host heterogeneity meets parasite polymorphism. Proc Biol Sci 261: 271‑277. PDF
  2. Gilbert SC, Plebanski M, Gupta S, Morris J, Cox M, Aidoo M, Kwiatkowski D, Greenwood BM, Whittle HC & Hill AVS (1998) Association of malaria parasite population structure, HLA, and immunological antagonism. Science 279: 1173‑1177. PDF