My research interests lie in the spatial epidemiology and population genetics of haemoglobin disorders, in particular alpha-thalassaemia and sickle cell anaemia. I use pre-existing epidemiological data and a combination of mathematical modelling and spatial statistics to: (i) develop up-to-date population estimates of severe alpha-thalassaemia cases at national and regional levels, (ii) explore the public health consequences of epistatic interactions between the two disorders in India, and (iii) investigate the malaria hypothesis at national scale. Previously, I have used stochastic population genetic models to explore evolutionary explanations for the current distribution of sickle-cell haplotypes in Africa and elsewhere.
Hockham C, Piel FB, Gupta S, Penman BS (2015) Understanding the contrasting spatial haplotype patterns of malaria-protective beta-globin polymorphisms. Infection Genetics and Evolution, 36:174-183
Tel: +44 (0) 01865 281 845