I am interested in mathematical modelling of the within-host dynamics of virus infection, specifically that of the human T-cell lymphotropic virus type 1 (HTLV-I). My research focus is on the unresolved issues of viral persistence and pathogenesis: How is the virus able to persist and avoid viral clearance despite the presence of vigorous positive selection by host immunity? What are the key factors that determine HTLV-I-associated disease progression?
Formulating and analysing mathematical models could help offer insights into the complex mechanisms underlying HTLV-I infection and persistence. A deeper understanding of these issues is a crucial step to developing effective ways to disrupt the virus life-cycle and may help identify promising new treatment strategies to reduce the severity of HTLV-I infection and associated disease.
Tel: +44 (0) 1865 281 309
- Li, M. Y. and Lim, A. G. (2011). Modelling the Role of Tax Expression in HTLV-I Persistence in vivo. Bull. Math. Biol. 73(12):3008-29.